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KMID : 0613820110210121789
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Journal of Life Science
2011 Volume.21 No. 12 p.1789 ~ p.1794
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Sarijang Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells
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Jin Cheng-Yun
Han Min-Ho
Park Cheol
Hwang Hye-Jin
Choi Eun-A
Choi Yung-Hyun
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Abstract
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Dendritic cells (DCs) are professional antigen-presenting cells playing key roles in immune sentinels as initiators of T-cell responses against microbial pathogens and tumors. Sarijang, a folk sauce containing extracts of Rhynchosia nulubilis, Ulmus davidiana roots, Allium sativum, and Rhus Verniaiflura bark, has been used as a nonspecific immunostimulant for cancer patients. However, little is known about its immunomodulating effects or their mechanisms. In this study, we investigated whether sarijang induces phenotypic and functional maturation of DCs. For this study, murine bone marrow-derived myeloid DCs were cultured in the presence of interleukin-4 (IL-4) and granulocyte-macrophage colony stimulating factor (GM-CSF), and the generated immature DCs were stimulated with sarijang or lipopolysaccharide (LPS). Our data indicated that sarijang significantly enhanced the expression of co-stimulatory molecules (CD80 and CD86) as well as major histocompatibility complex (MHC) II, as did LPS. The results provide new insight into the immunopharmacology of sarijang and suggest a novel approach to the manipulation of DC for therapeutic application.
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KEYWORD
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Sarijang, dendritic cells, maturation
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